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What is low level laser therapy devices?

What is low level laser therapy devices?

low level laser therapy devices

 

low level laser therapy devices

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low level laser therapy devices

What is low level laser therapy devices?-low level laser therapy devices (Low Level Laser Therapy) is the application of red and near infra-red light over injuries or lesions to improve wound and soft tissue healing, reduce inflammation and give relief for both acute and chronic pain. First developed in 1967, it is now commonly referred to as low level laser therapy devices.

low level laser therapy devices is used to: increase the speed, quality and tensile strength of tissue repair; resolve inflammation and relieve pain (analgesia).

The red and near infrared light (600nm-1000nm) commonly used in low level laser therapy devices can be produced by laser or high intensity LEDs. The intensity of low level laser therapy devices lasers and LED’s is not high like a surgical laser. There is no heating effect.

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The effects of low level laser therapy devices are photochemical (like photosynthesis in plants). When the correct intensity and treatment times are used, red and near infrared light reduces oxidative stress and increases ATP. This improves cell metabolism and reduce inflammation. These effects can be enhanced with pulses however when analgesia is required there is a second mechanism which works best when a strong continuous beam is applied.

low level laser therapy devices devices are typically delivering 10mW – 500mW (0.01 -> 0.01 Watts). The power density typically ranges from 0.005W/Cm² -> 5 W/Cm².

low level laser therapy devices is popularly used for soft tissue injuries, joint conditions, neuropathic pain, non-healing leg and pressure ulcers.

NEWS The Lancet publishes landmark review of low level laser therapy devices for neck pain read more and listen to interview here
Introduction to low level laser therapy devices Video

Introduction to low level laser therapy devices and dose response by Prof. Michael Hamblin, Wellman Centre for Photomedicine, Harvard Medical School
Source: International Dose Response Society

Download ‘low level laser therapy devices dose review (PDF)’
This paper from Harvard Medical School reviews the low level laser therapy devices mechanisms and the biphasic dose response. It summarises the molecular and cellular mechanisms of low level laser therapy devices, gives a scientific explanation for the biphasic dose response (why a low dose has a stimulatory effect and why a high dose inhibits). Low power densities tend to get better healing and anti-inflammatory effects where higher power densities are more likely to inhibit (which may be useful if you just want an analgesic effect). I have to disclose an interest in this paper because I am a co-author. James Carroll CEO THOR Photomedicine.

How low level laser therapy devices work?

How low level laser therapy devices work?-For low-power visible or near-infrared light to have an effect on a biologic system, the photon must be absorbed by electronic absorption bands belonging to a photon acceptor or chromophore (first law of photobiology) . A chromophore is a molecule (or portion of a molecule) which imparts a color to a compound (e.g. chlorophyll, hemoglobin, myoglobin, cytochrome c oxidase, other cytochromes, flavin, flavoproteins or porphyrins) . The “optical window” in a tissue describes a range of wavelengths where the penetration of light into tissue is maximized by employing red and near-infrared wavelengths . The optimum wavelength has been estimated to be around 810 nm. Mitochondria are “the cellular power plants” in our cells and as such they convert food molecules and oxygen into energy (ATP) by oxidative phosphorylation. It has been proposed that cytochrome c oxidase (COX) is the primary photo-acceptor for the red-NIR wavelength range in mammalian cells . Nitric oxide (NO) produced in mitochondria can inhibit respiration by binding to COX and displace oxygen especially in injured or hypoxic cells . It is proposed that low level laser therapy devices can photo-dissociate NO from COX and reverse the mitochondrial inhibition of respiration due to excessive NO binding . The process of light mediated vasodilation was first described by RF Furchgott in 1968, and his research on the biological properties of nitric oxide eventually led to the award of a Nobel Prize in 1998 . low level laser therapy devices is able to produce a shift in the overall cell redox potential in the direction of greater oxidation by increasing reactive oxygen species (ROS) and decreasing reactive nitrogen species (RNS). The long-term effects of low level laser therapy devices are thought to be due to the activation of various transcription factors by the immediate chemical signaling molecules produce from mitochondrial stimulation by low level laser therapy devices. The most important of these signaling molecules are thought to be ATP, cyclic-AMP, NO and ROS .

low level laser therapy devices at low doses has been shown to enhance cell proliferation of fibroblasts , keratinocytes, endothelial cells and lymphocytes . The mechanism of proliferation is thought to result from photo-stimulation of the mitochondria leading to activation of signaling pathways and up regulation of transcription factors eventually giving rise to increases in growth factors . low level laser therapy devices can enhance neovascularization, promote angiogenesis and increase collagen synthesis to aid in the healing of acute and chronic wounds . It has been observed in many studies, that low level laser therapy devices exhibits a biphasic dose response curve, where by lower doses of light are more effective than much higher doses. These low doses of light have demonstrated the ability to heal skin, nerves, tendons, cartilage and bones.

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Why we need low level laser therapy devices?

The three benefits of low level laser therapy devices are it improves wound tissue regeneration, reduces inflammation and has an analgesic effect.

low level laser therapy devices may sometimes provide an effective alternative to surgery or medications—without accompanying side effects. It can help regenerate tissue, reduce inflammation, decrease pain, and increase immunity, and research has shown its efficacy in treating many conditions, including:

Plantar fasciitis
Rheumatoid arthritis
Temporomandibular joint disorder
Exercise-induced muscle fatigue and injury prevention
Skin conditions
Traumatic brain injury
Stroke

These three PDF files summarise the effects of low level laser therapy devices and clinical benefits for:

Wound Healing
Sports injuries
Chronic Pain

 


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